Crack initiation and growth in wood-based materials, commonly employed in buildings and civil engineering structures, still generate considerable inspection and repair costs besides the fact that is one of the most important factors involved in structural failure. X-ray computed microtomography (X-ray CT), which provides 3D images with a high level of detail at both the micro- and macro-scales, is frequently used as a non-destructive technique. In this work, the propagation of a 20 mm initial crack in Mixed-Mode Crack Growth (MMCG) wood samples was tracked using high-energy X-ray CT. Crack growth data were then determined from 3D tomography reconstructions. 2D crack tracking data measurements from fracture surface were performed using 2D Digital Image Correlation (DIC) analysis method. The collected 3D measurements were compared to those obtained from 2D DIC analysis and conventional mechanical tests in order to measure long and small crack growth. The observed results demonstrates that X-ray CT and surface tracking analysis usingDICgrid methodcan be successfully combined to study the crack propagation